Impaired presynaptic inhibition in the motor cortex in Parkinson disease.
Identifieur interne : 001E37 ( Main/Exploration ); précédent : 001E36; suivant : 001E38Impaired presynaptic inhibition in the motor cortex in Parkinson disease.
Auteurs : J. Chu [Canada] ; A. Wagle-Shukla ; C. Gunraj ; A E Lang ; R. ChenSource :
- Neurology [ 1526-632X ] ; 2009.
English descriptors
- KwdEn :
- Aged, Electromyography (methods), Evoked Potentials, Motor (physiology), Female, Humans, Male, Middle Aged, Motor Cortex (pathology), Motor Cortex (physiology), Neural Inhibition (physiology), Parkinson Disease (physiopathology), Presynaptic Terminals (pathology), Presynaptic Terminals (physiology), Transcranial Magnetic Stimulation (methods).
- MESH :
- methods : Electromyography, Transcranial Magnetic Stimulation.
- pathology : Motor Cortex, Presynaptic Terminals.
- physiology : Evoked Potentials, Motor, Motor Cortex, Neural Inhibition, Presynaptic Terminals.
- physiopathology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABA(A) receptors, and long interval intracortical inhibition (LICI), likely mediated by GABA(B) receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABA(B) mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired.
DOI: 10.1212/01.wnl.0000343881.27524.e8
PubMed: 19255412
Affiliations:
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Le document en format XML
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Wagle-Shukla</name></author><author><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C" last="Gunraj">C. Gunraj</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R" last="Chen">R. Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19255412</idno><idno type="pmid">19255412</idno><idno type="doi">10.1212/01.wnl.0000343881.27524.e8</idno><idno type="wicri:Area/PubMed/Corpus">000E89</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E89</idno><idno type="wicri:Area/PubMed/Curation">000E89</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E89</idno><idno type="wicri:Area/PubMed/Checkpoint">000E89</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E89</idno><idno type="wicri:Area/Ncbi/Merge">000A40</idno><idno type="wicri:Area/Ncbi/Curation">000A40</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A40</idno><idno type="wicri:Area/Main/Merge">001F87</idno><idno type="wicri:Area/Main/Curation">001E37</idno><idno type="wicri:Area/Main/Exploration">001E37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired presynaptic inhibition in the motor cortex in Parkinson disease.</title><author><name sortKey="Chu, J" sort="Chu, J" uniqKey="Chu J" first="J" last="Chu">J. Chu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A" last="Wagle-Shukla">A. Wagle-Shukla</name></author><author><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C" last="Gunraj">C. Gunraj</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R" last="Chen">R. Chen</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Electromyography (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (pathology)</term><term>Motor Cortex (physiology)</term><term>Neural Inhibition (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Presynaptic Terminals (pathology)</term><term>Presynaptic Terminals (physiology)</term><term>Transcranial Magnetic Stimulation (methods)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Motor Cortex</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Motor Cortex</term><term>Neural Inhibition</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABA(A) receptors, and long interval intracortical inhibition (LICI), likely mediated by GABA(B) receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABA(B) mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R" last="Chen">R. Chen</name><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C" last="Gunraj">C. Gunraj</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A" last="Wagle-Shukla">A. Wagle-Shukla</name></noCountry><country name="Canada"><noRegion><name sortKey="Chu, J" sort="Chu, J" uniqKey="Chu J" first="J" last="Chu">J. 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